What genetic engineering techniques were available to engineer SARS-1 and SARS-CoV-2? Is evidence of their use imprinted on the genome? Don't try this at home!
<<We can’t detect, let alone stop people engineering novel bioweapons. So we must learn to attribute - to discern between artificial and natural pathogens. >>
This can only happen with a shift such that by convention ALL novel virology encounters are treated as deliberate anomalous health events first, in parallel with fair weather Discrepant Epidemiology thinking…
Why? Because it turns out only one extinction level event is enough.
These biostrategic concerns, investigations and gains are hard won.
But according to the best of the fair weather crowd the main problem is that our very biological existence means we are uniquely vulnerable to Biological Warfare.
If we want to be around much longer we are going to have to do better than this defeatist approach.
PRC/PLA system has built in the survival from these weapons into the basics of their economic planning well before COVID;
<<The year 2020 provided two rare windows into this underlying design. The first came in April, when Xi addressed the Central Financial and Economic Affairs Commission and laid out what became the doctrinal foundation for the 14th Five-Year Plan. The speech, later published in Qiushi as “Several Major Issues Concerning the National Medium- and Long-Term Economic and Social Development Strategy” (国家中长期经济社会发展战略若干重大问题), described the pandemic not as an exogenous crisis but as a “stress test” (压力测试) of a “great power” (大国) industrialized economic system already under construction (Qiushi, October 31, 2020). Xi defined a great power economy’s advantage as the capacity to circulate internally while drawing the world into its orbit. In his words, to build redundant, “autonomous, controllable, secure, and reliable” (自主可控、安全可靠) supply chains, ensure that each critical input had a domestic backup, and “tighten the dependence of international industrial chains on China, forming a strong countermeasure and deterrent capability against deliberate supply disruptions from foreign countries” (拉紧国际产业链对我国的依存关系，形成对外方人为断供的强有力反制和威慑能力). In practice, this translated into an offensive form of resilience: import substitution to guard against coercion and economic leverage to inflict it. The same speech directed officials to “forge killer technologies” (‘杀手锏’技术) and strengthen the PRC’s “complete industrial chain advantages” (持续增强 … 全产业链优势) in critical industries such as new energy and telecommunications. This phrasing signaled the emergence of industrial policy as a security instrument. Xi outlined the rapid accumulation of competitive capabilities through weaponized economic survivability, a pressure-tested and “self-sustaining” system of economic operation in which resilience and retaliation became two sides of the same structure. This was the strategic closure of a process begun years earlier, turning the “new development pattern” into a national security economy capable of functioning even under “extreme conditions” (极端情况).>>
Is there any research on the effect on original british , french, ace2 receptor?are there differentioations on regions? Like adaption of vit d need and thus different modifications of ace2 or antibodies or peptides or …?
There are certainly ACE2 variants at level of ethnicity. I'm not sure about the level of regions/countries or whether differences lead to significantly different outcomes.
very interesting, thanks.
<<We can’t detect, let alone stop people engineering novel bioweapons. So we must learn to attribute - to discern between artificial and natural pathogens. >>
This can only happen with a shift such that by convention ALL novel virology encounters are treated as deliberate anomalous health events first, in parallel with fair weather Discrepant Epidemiology thinking…
Why? Because it turns out only one extinction level event is enough.
These biostrategic concerns, investigations and gains are hard won.
https://x.com/tommy_cleary/status/1981412052288876845?s=46
Institutions are simply not built to understand or investigate these issues.
https://www.hoover.org/research-teams/bio-strategies-and-leadership
Governments of all types reach for silencing…
https://pubmed.ncbi.nlm.nih.gov/9660291/
From a data transparency perspective even aspects of Iraq,
https://www.blackincbooks.com.au/books/weapons-detective
& BW WMD are still not available.
https://pubmed.ncbi.nlm.nih.gov/9244334/#:~:text=Abstract,of%20weapons%20of%20mass%20destruction.
Thus AI assisted biostrategic forensics are important…
https://biosafetynow.substack.com/p/gobbledygook/comment/172303352?r=9kr7t&utm_medium=ios
But according to the best of the fair weather crowd the main problem is that our very biological existence means we are uniquely vulnerable to Biological Warfare.
https://open.substack.com/pub/biosafetynow/p/ai-assisted-design-of-viruses?utm_campaign=post&utm_medium=web
If we want to be around much longer we are going to have to do better than this defeatist approach.
PRC/PLA system has built in the survival from these weapons into the basics of their economic planning well before COVID;
<<The year 2020 provided two rare windows into this underlying design. The first came in April, when Xi addressed the Central Financial and Economic Affairs Commission and laid out what became the doctrinal foundation for the 14th Five-Year Plan. The speech, later published in Qiushi as “Several Major Issues Concerning the National Medium- and Long-Term Economic and Social Development Strategy” (国家中长期经济社会发展战略若干重大问题), described the pandemic not as an exogenous crisis but as a “stress test” (压力测试) of a “great power” (大国) industrialized economic system already under construction (Qiushi, October 31, 2020). Xi defined a great power economy’s advantage as the capacity to circulate internally while drawing the world into its orbit. In his words, to build redundant, “autonomous, controllable, secure, and reliable” (自主可控、安全可靠) supply chains, ensure that each critical input had a domestic backup, and “tighten the dependence of international industrial chains on China, forming a strong countermeasure and deterrent capability against deliberate supply disruptions from foreign countries” (拉紧国际产业链对我国的依存关系，形成对外方人为断供的强有力反制和威慑能力). In practice, this translated into an offensive form of resilience: import substitution to guard against coercion and economic leverage to inflict it. The same speech directed officials to “forge killer technologies” (‘杀手锏’技术) and strengthen the PRC’s “complete industrial chain advantages” (持续增强 … 全产业链优势) in critical industries such as new energy and telecommunications. This phrasing signaled the emergence of industrial policy as a security instrument. Xi outlined the rapid accumulation of competitive capabilities through weaponized economic survivability, a pressure-tested and “self-sustaining” system of economic operation in which resilience and retaliation became two sides of the same structure. This was the strategic closure of a process begun years earlier, turning the “new development pattern” into a national security economy capable of functioning even under “extreme conditions” (极端情况).>>
https://jamestown.org/program/a-five-year-plan-for-managed-confrontation/
Meanwhile the US seemed to be developing an understanding of these issues from 2021-2023 but then in 2024 cowardice took over again.
https://www.dni.gov/files/ODNI/documents/assessments/ATA-2023-Unclassified-Report.pdf#page33
In short Dr J thank you for your unflinching approach.
Go for No is our only method to survive this mess.
good ideas!
I proposed that years ago, as I did that in my PhD https://drbine-substack-com.translate.goog/p/directed-protein-evolution?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=de&_x_tr_pto=wapp
I wrote that years ago, because I used that methods in my PhD https://drbine-substack-com.translate.goog/p/directed-protein-evolution?_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=de&_x_tr_pto=wapp
Is there any research on the effect on original british , french, ace2 receptor?are there differentioations on regions? Like adaption of vit d need and thus different modifications of ace2 or antibodies or peptides or …?
There are certainly ACE2 variants at level of ethnicity. I'm not sure about the level of regions/countries or whether differences lead to significantly different outcomes.
A very interesting article. Thanks.
Excellent article thanks